Award details

The role of central metabolism in the successful infection of macrophages by Salmonella typhimurium

Reference	BBS/E/F/00042073
Principal Investigator / Supervisor	Dr Arthur Thompson
Co-Investigators / Co-Supervisors	Professor Jay Hinton
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	178,625
Status	Completed
Type	Institute Project
Start date	01/07/2006
End date	30/06/2009
Duration	36 months

Abstract

This proposal aims to determine whether sugars and fats are used as fuel by the Salmonella during infection. We will do this by blocking the manufacture of specific enzymes and transport proteins involved in the fuel breakdown pathways and seeing whether this reduces the ability of Salmonella to survive inside the SCV. We will find out whether the same fuel or different types of fuel are used during infection. Macrophages also make a chemical called interferon that stimulates the breakdown pathways of fat in other species of bacteria that live inside macrophages. When these pathways are blocked by stopping specific enzymes involved in the pathway from being produced, the survival of bacteria is reduced. We aim to find out whether interferon stimulates similar breakdown pathways in Salmonella, and whether blocking these pathways also reduces infection. Identification of the breakdown pathways and the chemicals used by Salmonella to survive inside the macrophage is likely to suggest ways of preventing Salmonella infections.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Animal Health, Immunology, Microbial Food Safety, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search