Award details

Molecular microbiology of the GI tract

Reference	BBS/E/F/00041771
Principal Investigator / Supervisor	Dr Tracy Eaton
Co-Investigators / Co-Supervisors	Professor Michael Gasson
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	206,343
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2005
Duration	24 months

Abstract

The human gut harbours a population of some 100 trillion bacteria. The numbers in the stomach and small intestine are relatively low but in the large intestine their levels reach more than a billion cells per gram of gut contents. These bacteria colonise the gut from birth and the maintenance of a balanced flora is essential for a healthy gut. More than 400 different species are known to be present in the gut but many bacterial species cannot be grown in vitro. This project aims to develop molecular methods to identify and understand the population dynamics of these complex microbial communities. The project will evaluate available molecular approaches and develop new methods with which to study the gastro-intestinal tract microflora. Robust, high throughput systems are required in order to accurately and quantitatively analyse large numbers of samples. Molecular methodologies being used include: denaturing gradient gel electrophoresis; GC profiling combined with 16S rRNA sequence data analysis; oligonucleotide fingerprinting of ribosomal genes (OFRG) using microarray technology

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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