Award details

Chemical profiling (reorganisation of 4211225A into two projects: this and 4231770A)

Reference	BBS/E/F/00041769
Principal Investigator / Supervisor	Dr Ian Colquhoun
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	196,233
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2005
Duration	24 months

Abstract

The aim is to establish profiling methods for analysis of plants and bacteria (metabolomics) and for authentication of foods. In the first case the methods will be used to determine the effects of controlled genetic and/or environmental influences on metabolite composition. The methods should be non-targeted (in terms of classes of chemical compound) and comprehensive as well as being as high throughput as possible. Advanced data mining procedures are required to generate hypotheses from the data (link to 4231770A). This is a continuation of previous projects in which protocols have been developed for high resolution NMR. The immediate aims are to extend and validate LC/MS protocols for secondary metabolites and to establish similar protocols mainly for primary metabolites using GC/MS. The methods are being developed using material from GM and control potato tubers. In authentication the emphasis will be on the use of isotope ratio mass spectrometry to establish novel biomarkers for the geographical origin of foods (e.g. to measure strontium isotope ratios in olive oil as an indicator of origin) and to use natural isotope fractionation of minerals in foods as an indicator of production methods e.g. zinc isotopes in cattle and poultry in relation to feeding regime

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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