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Dietary modulation of immune function in relation to type 2 diabetes and cardiovascular disease risk

Reference	BBS/E/F/00041694
Principal Investigator / Supervisor	Dr David Hughes
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	354,578
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2005
Duration	24 months

Abstract

Cardiovascular disease (CVD) is a major cause of mortality in the UK and is likely to rise further given the increasing prevalence of obesity and related rise in the incidence of Type 2 diabetes. Diabetes is associated with an increased risk of early-onset atherosclerosis (thickening of the artery walls). This is now recognised as an inflammatory disease occurring in all adults to a greater or lesser extent. Monocytes and T lymphocytes (mononuclear cells) are crucial cell types in the genesis of the atherosclerotic lesion and are present during all stages of disease progression. In terms of reduced CVD risk, numerous epidemiological & prospective studies have indicated beneficial effects of increased vitamin E and n-3 fatty acid intake, as well as of increased fruit and vegetable consumption. In collaboration with the Diabetes Research Centre, Norfolk & Norwich University Hospital, we will examine differences in mononuclear cell function, at the molecular and cellular level, between healthy volunteers and patients with Type 2 diabetes, and investigate novel mechanisms of the beneficial effects of dietary components, in terms of reducing CVD risk, on human immune cell function

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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