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Anticarcinogenic activity of crucifers: Transcriptome analysis of human colon cells following exposure to extracts of broccoli and Arabidopsis
Reference
BBS/E/F/00041692
Principal Investigator / Supervisor
Professor Richard Mithen
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
20,682
Status
Completed
Type
Institute Project
Start date
18/07/2003
End date
27/05/2006
Duration
34 months
Abstract
Epidemiological and physiological studies have provided substantial evidence that consumption of crucifers significantly reduces the risk of cancer. Several possible mechanisms have been proposed, many of which implicate glucosinolates and their degradation products, which include isothiocyanates (ITCs) and indolyl compounds. We propose to study changes in gene expression in human colon cell cultures with Affymetrix Human GeneChipTM U133 microarrays, following treatment with extracts of broccoli and isothiocyanate-enriched broccoli, and pure compounds. We will also compare the effect of broccoli extracts on gene expression with that of Arabidopsis extracts, and evaluate the potential to develop Arabidopsis as a model system to study the anticarcinogenic effect of crucifers.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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