BBSRC Portfolio Analyser
Award details
Generation of new natural and non-natural lanti-biotics by genome mining and pathway engineering
Reference
BBS/E/F/00041675
Principal Investigator / Supervisor
Professor Michael Gasson
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
6,776
Status
Completed
Type
Institute Project
Start date
01/01/2004
End date
31/12/2005
Duration
24 months
Abstract
Lantibiotics are a diverse group of highly modified peptides produced by Gram positive bacteria. They are so called because of the presence of lanthionine ring(s) within their structures. A-type lantibiotics, such as nisin, have pore forming antibiotic activities, whereas the B-type lantibiotics exhibit a diverse range of biological activities. The objectives of this project are to use functional genomics to discover new lantibiotic pathways; to understand in detail the functions of the genes for synthesis of the lantibiotic cinnamycin and to develop effective methods for generating cinnamycin variants. The discoveries made within the programme will be exploited to develop novel therapeutic lantibiotics.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search