Award details

Development of novel anti-bacterials and anti-infectives that target programmed bacterial cell death (BAS anti-microbials)

Reference	BBS/E/F/00041414
Principal Investigator / Supervisor	Dr Jerry Wells
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	160,883
Status	Completed
Type	Institute Project
Start date	01/01/2002
End date	31/12/2004
Duration	36 months

Abstract

The goal of our project is to exploit certain suicide modules (toxin -antitoxin protein pairs) found in bacteria for the development of novel antimicrobial drugs. The best known examples of such suicide modules are associated with the control of plasmid partitioning during bacterial replication (e.g. ccdA, ccdB). We aim to identify the mode of action of the toxin for a number of suicide systems found in different bacteria. By determining the protein structure of the cellular targets and the toxin itself we hope to be able to design drugs that mimic the action of the toxin. Our main task is to use genomics tools to gain a better understanding of the external conditions and processes within the bacteria that lead to bacterial programmed cell death

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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