Award details

Gut immunology

Reference	BBS/E/F/00041387
Principal Investigator / Supervisor	Dr Claudio Nicoletti
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	968,079
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2005
Duration	48 months

Abstract

Our group is focusing on several aspects of gut immunology. It is our intention to dissect in details the interactions between lymphocytes and intestinal epithelial cells and to identify cellular and molecular events, which are instrumental in the maintenance of functions of the highly specialized intestinal epithelium. Part of the project will also involve the study of interaction of food-borne pathogens (e.g. Salmonella) with the intestinal epithelium and immune system, and we are particularly interested in understanding the role of dendritic cells in directing the pathogen-specific T cell response in a relevant human model. By using cutting-edge molecular biology techniques, we plan to study the host responses at molecular level. A different line of research is devoted to the study of cellular and molecular basis of food allergy. At this time we are focusing our attention on the role of professional antigen-presenting cells in the gut and the main goal of this project is to identify early events taking place in the organized gut associated lymphoid tissue following interaction of putative allergens. We also plan to investigate the role of human antigen-presenting cells of different origin (mucosal or systemic) in regulating immune responses in physiological as well as pathological conditions

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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