Award details

Gene expression and response in real food systems

Reference	BBS/E/F/00041211
Principal Investigator / Supervisor	Professor Tim Brocklehurst
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	1,116,646
Status	Completed
Type	Institute Project
Start date	01/04/2000
End date	31/03/2005
Duration	60 months

Abstract

This project is concerned with the effect of food structure on microbial growth. It has been established that food structure perturbs lag time, growth rate and the boundaries of the growth. The observed effects are commonly a reduction in growth rate, an extension of the lag time, and a shrinking of the habitat domain, although in some cases the colonial state results in faster growth. A common feature of these phenomena is the growth of the organisms in colonies, rather than as plankton. The aim is to determine the mechanisms of these effects. Local stress conditions within colonies represent potential sites for bacterial adaptation by selective gene expression. The modification of the local environment within and around bacterial colonies will be predicted using cellular automaton computer tools, rate and stoichiometric constants derived from bioreactor technology and validation by fluorescence techniques. The effect of modification of the local environment on gene expression associated with stress response and virulence will be studied using reporter gene fusion¿s

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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