Award details

Cell and molecular biology of the gut

Reference	BBS/E/F/00041035
Principal Investigator / Supervisor	Dr Ian Johnson
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	2,587,186
Status	Completed
Type	Institute Project
Start date	01/04/1999
End date	31/03/2005
Duration	72 months

Abstract

The mucosal surfaces of the human bowel provide both the route of access for all nutrients, and a barrier which protects the internal environment from infectious agents and toxic substances. These vital functions are maintained by continuous proliferation and loss of epithelial cells, which are prone to diet-related disease. The colon in particular is a major site for both cancers and chronic inflammatory conditions of unknown origin. The objective of this project will be to gain a better understanding of the food-related mechanisms which influence mucosal integrity, and hence the health of the human gut. The research will be conducted at the molecular, cellular and whole organ level, using in vitro techniques, animal models, and human studies. The work-plan will build upon our own recent progress in the area, taking account of emerging opportunities identified in the literature, and will be divided into four main Tasks: 1. Free-radical mediated signal transduction and the regulation of crypt cell apoptosis. 2. Modulation of epithelial mitosis and apoptosis via receptor-mediated interactions with food-borne phytochemicals. 3. The role of diet-mediated DNA methylation and histone acetylation in the regulation of mucosal cell gene expression and epithelial integrity. 4. Regulation of mucosal mineral transporters

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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