Award details

Designing and improving health and food related production processes using filamentous fungal cell factories (EUROFUNG 2)

Reference	BBS/E/F/00041018
Principal Investigator / Supervisor	Dr Ian Roberts
Co-Investigators / Co-Supervisors
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	123,829
Status	Completed
Type	Institute Project
Start date	01/02/2000
End date	31/07/2003
Duration	42 months

Abstract

Filamentous fungi are known for their ability to produce metabolites important for human health (antibiotics) and enzymes used in the food and feed industry. They are promising hosts for the production of pharmaceutical proteins, antibodies and vaccines and of novel non-ribosomal peptide antibiotics. The project designs versatile filamentous fungal cell factories for different products by pinpointing and eliminating the major bottle-necks which limit their efficiency. A first objective is to improve the ability of fungi to make foreign proteins by better understanding the secretion process. The second objective is to increase fungal production rates and improve substrate utilisation. Thirdly, new fungal antibiotics are developed to replace existing antibiotics for which bacterial resistance appears.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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