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The kinetics of lymphocytes and monocytes in vivo.
Reference
BBS/E/E/0ME/5/03
Principal Investigator / Supervisor
Professor Peter Beverley
Co-Investigators /
Co-Supervisors
Institution
Edward Jenner Institute for Vaccine Res
Department
Scientific Head
Funding type
Research
Value (£)
23,000
Status
Completed
Type
Institute Project
Start date
19/06/2003
End date
18/06/2005
Duration
24 months
Abstract
We use administration of deuterated glucose to label dividing cells in vivo in humans. Mononuclear cell subsets are subsequently separated by fluorescence activated cell sorting and the deuterium/hydrogen ratio in DNA measured by gas chromatography mass spectrometry. This has allowed us to describe the kinetics of naive and memory T and B lymphocytes in healthy young and elderly individuals, as well as deviations from normal in acute and chronic diseases.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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