Award details

Cytokine regulation of T cell turnover and lifespan in vivo

Reference	BBS/E/E/0ME/4/98
Principal Investigator / Supervisor	Dr David Tough
Co-Investigators / Co-Supervisors	Dr Jonathan Sprent
Institution	Edward Jenner Institute for Vaccine Res
Department	Scientific Head
Funding type	Research
Value (£)	32,000
Status	Completed
Type	Institute Project
Start date	01/01/2000
End date	22/07/2002
Duration	31 months

Abstract

Mucosal tissues such as the intestine and lung are sites for the entry of many infectious agents (eg. HIV) into the body. Therefore, generating memory cells that function at these sites is an important goal of vaccination. At present, little is known about the properties of T and B memory cells in the mucosa, or the requirements for optimal formulation and delivery of a vaccine that will induce mucosal immunity. In this project, we will study the regulation of T cell memory in the intestinal mucosa. We will compare the immune response elicited following administration of different vaccine formulations (eg. purified proteins or virus-associated molecules) given by oral or other routes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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