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Measurement of in vivo lymphocyte and monocyte kinetics in health and disease in man

Reference	BBS/E/E/0ME/1/98
Principal Investigator / Supervisor	Dr David Tough
Co-Investigators / Co-Supervisors	Professor Peter Beverley, Professor Derek Macallan
Institution	Edward Jenner Institute for Vaccine Res
Department	Scientific Head
Funding type	Research
Value (£)	63,000
Status	Completed
Type	Institute Project
Start date	01/10/1998
End date	31/12/2002
Duration	51 months

Abstract

Lymphocytes and monocytes are white blood cells, which have an important role in co-ordinating the body's response to infection. If the number or activity of these cells is disturbed, as occurs in HIV infection and AIDS, immunity is impaired. Our understanding of how the number of white blood cells in the body is controlled is very limited and we do not even know accurately how long these cells live under normal conditions. In this project we are using deuterated glucose to label dividing cells in vivo. Following labelling several subsets of lymphocytes can be isolated from peripheral blood samples and their rate of cell division estimated by measuring deuterium incorporated into DNA. Initial results show large differences between na¿ve and memory lymnpocytes and very rapid cell division during acute infection.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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