Award details

Immunity Following Vaccination in Early Life

Reference	BBS/E/E/0CD/4/02
Principal Investigator / Supervisor	Professor Peter Beverley
Co-Investigators / Co-Supervisors	Dr D Marchant, Dr R Moxon, Dr D Pollard
Institution	Edward Jenner Institute for Vaccine Res
Department	Scientific Head
Funding type	Research
Value (£)	52,000
Status	Completed
Type	Institute Project
Start date	01/10/2002
End date	30/09/2003
Duration	12 months

Abstract

Little is known about the cellular and molecular basis for differences in the immune response to protein-polysaccharide conjugate vaccines between infants and adults or even between different individuals. This collaborative project between EJIVR and the Department of Paediatrics, University of Oxford aims to characterise immune responses to these vaccines in infants with the longer term view of facilitating optimal immunisation strategies. In the initial period of the project the focus has been on assay development and ELISPOT protocols for detection of antigen specific IgG antibody secreting cells (ASC) and IFNg -secreting T-cells have been established as well as molecular methods for analysis of the immunoglobulin VH gene and T cell receptor Vb repertoire. These cellular and molecular methods will now be used to evaluate the magnitude and repertoire of the infant immune response to glyconjugate vaccines and the duration of immunological memory.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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