Award details

Polymorphism and disease associated with the CD45 locus

Reference	BBS/E/E/0CD/3/01
Principal Investigator / Supervisor	Professor Peter Beverley
Co-Investigators / Co-Supervisors	Dr N Bodmer
Institution	Edward Jenner Institute for Vaccine Res
Department	Scientific Head
Funding type	Research
Value (£)	35,000
Status	Completed
Type	Institute Project
Start date	05/11/2001
End date	04/11/2004
Duration	36 months

Abstract

This project will use rapid DNA screening methods to examine the geographical distribution of the C77G allele, that has been associated with multiple sclerosis and HIV infection. We will also search for new polymorphisms of CD45 using PCR- based methods in ethnically diverse samples. If new polymorphisms are found, disease associations of these will be investigated using sample sets availble to us. Rapid methods for determining CD45 haplotypes will be established for future studies of disease associations. Polymorphisms in regions of the gene affecting splicing will be investigated using spliceable minigene constructs. We will also screen for other immune-function related polymorphisms in the same sample sets.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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