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The function of the CD45 molecule

Reference	BBS/E/E/0CD/2/01
Principal Investigator / Supervisor	Professor Peter Beverley
Co-Investigators / Co-Supervisors	Dr D Cantrell
Institution	Edward Jenner Institute for Vaccine Res
Department	Scientific Head
Funding type	Research
Value (£)	20,000
Status	Completed
Type	Institute Project
Start date	01/10/2001
End date	30/09/2004
Duration	36 months

Abstract

This project will address the role of different CD45 isoforms in signalling through the T cell receptor, focussing on three pathways. These are the PI3 kinase, serine kinase and guanine nucleotide binding protein pathways. The Cantrell group has made transgenic mice expressing activated Rho (a GTP-binding protein and these mice have excessive numbers of "memory" phenotype cells. EJIVR has made several mice expressing single CD45 isoforms. These mice will provide tools to study these signalling pathways in cells with naive or memory phenotype and may shed light on the the events that control formation of memory cells. Experiments on the biochemistry of signalling will largely be carried out at CRUK and those on immune function in vivo, at EJIVR.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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