Award details

CD45 Group

Reference	BBS/E/E/0000CD00
Principal Investigator / Supervisor	Professor Peter Beverley
Co-Investigators / Co-Supervisors
Institution	Edward Jenner Institute for Vaccine Res
Department	Scientific Head
Funding type	Research
Value (£)	813,000
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/10/2005
Duration	103 months

Abstract

The aim of the group is to understand better the function of naive and memory T lymphocytes and apply this understanding to the more effective development of vaccines. We have shown that memory is dynamic and that memory cells turn over much more rapidly than naive T cells. We have also shown that CD4 and CD8 T cells are regulated very differently at the clonal level; while CD4 clones are small, CD8 clones may be very large. In humans we have studied clonal size using heteroduplex analysis and the lifespan of lymphocytes is followed in man using deuterated glucose to label dividing cells in vivo. The group continues to study factors that influence clone size and diversity in immune responses, using molecular methods to manipulate antigen presentation, costimuli and the cytokine milieu in mice. The role of different isoforms of CD45 is investigated by studying patients with abnormalities of CD45 expression and using transgenic mice expressing single isoforms.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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