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Award details
Novel strategies to control virus infection and disease
Reference
BBS/E/D/20241866
Principal Investigator / Supervisor
Professor Paul Digard
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
The Roslin Institute
Funding type
Research
Value (£)
1,042,337
Status
Completed
Type
Institute Project
Start date
01/04/2012
End date
31/03/2017
Duration
59 months
Abstract
Endemic and exotic virus diseases are threats to food security and, in some cases, potential zoonoses. We aim to develop novel strategies to control virus infection, focussing on improving animal welfare and reducing the disease burden in food production animals. The objectives include i) development of vaccines based around pox virus and herpesvirus delivery systems; ii) exploitation of transgenesis as a means of delivering resistance genes including antiviral peptides. Preliminary studies suggest that it is possible to prevent or reduce virus transmission, infection or disease by genetic modification of mammalian/avian hosts; iii) development of the concept of a bioshield involving constitutive expression of antiviral peptides expressed by probiotic bacteria colonisation of the GI tract.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Animal Health, Immunology, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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