Award details

Host genetic resistance to viruses

Reference	BBS/E/D/20241863
Principal Investigator / Supervisor	Professor Paul Digard
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	1,163,035
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

The outcomes of viral infections and the dynamics of host-pathogen interactions depend jointly upon the genotype of the host and the virus. For any viral strain, host genotype determines infection outcomes, extent and nature of pathology, and appropriate control strategies. Antiviral defences are divergent between species with gain and loss of genes and even entire gene families. For example, birds do not possess some of the genes involved in recognition of DNA viruses in mammals, and these genes are diversified amongst large mammals. Additionally, many viral infections have a limited host range and/or distinct pathology in different hosts. We aim to identify genetic loci controlling resistance and/or pathology, focussing on genetic variation within populations.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search