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Analysis of innate immune responses in vivo and the control of effective immune responses to infection

Reference	BBS/E/D/20231762
Principal Investigator / Supervisor	Professor David Gally
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	2,656,700
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

While studies of innate immune responses to stimulatory agonists and pathogens in in vitro systems will provide a powerful framework of knowledge on the nature and regulation of innate responses in the target animal species, responses to infection in vivo will also be influenced by the microenvironment in which the pathogen-host cell interaction occurs. Innate immune responses contribute to control of infection not only by triggering non-specific defense mechanisms but also by regulating the adaptive immune response. The latter operates largely through antigen-presenting cells (APC), and their capacity to influence differentiation of T lymphocytes. We aim to extend the work in earlier themes, by examining in vivo responses of APC to infection and their capacity to induce specific T cell responses. The work will focus particularly on intracellular pathogens and will include studies to characterise relevant subsets of APC and T lymphocytes in the target species.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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