Award details

Rational selection of targets for control of bacterial pathogens of food-producing animals

Reference	BBS/E/D/20231761
Principal Investigator / Supervisor	Professor David Gally
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	1,972,786
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

This project brings together scientists with expertise in diverse animal models and bacterial genetics to identify factors important for colonisation, host-specificity and pathogenesis. Although complete and partial genome sequences exist for the pathogens under study, the role of the encoded products in persistence, pathogenesis and protection needs to be evaluated. High-resolution comparative genomics and high-throughput in vivo and in vitro screens have identified bacterial determinants which are predicted to be important for these processes. We aim to determine how they function and examine their effect on innate and/or acquired responses in naïve or resistant hosts. The work will be integrated with studies on pathogen recognition (theme 1) and resistance (theme 2) and be exploited to develop and refine intervention strategies.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search