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The impact of host genetic variation on susceptibility and pathology

Reference	BBS/E/D/20231760
Principal Investigator / Supervisor	Professor David Gally
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	2,723,814
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

In this theme, we aim to pursue genetic variation underlying disease prevalence. By combining resistance data with genome mapping techniques we are able to define loci associated with resistance to a very wide range of infections in production animals. Genetic variation can impact upon every stage of infection from initial entry to the nature and resolution of pathology and subsequent memory responses. Each pathogen-host combination offers new challenges. Targets for study are prioritised on the basis of economic importance/impact and clear evidence of heritable resistance. The aim in each study is to link genotype to phenotype (e.g. variation in an innate immune response; difference in resistance to a pathogen) in a predictive manner. We will focus on (1) poultry infection by Salmonella and Campylobacter as sources of human infection. Some S. enterica serovars as well as avian pathogenic E. coli (APEC) also threaten poultry welfare and exert a substantial economic and welfare burden owing to their ability to migrate to systemic sites, causing fowl typhoid or colibacillosis respectively. (2) Mycobacterial infections of cattle and sheep.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbial Food Safety, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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