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Systems Biology of innate immunity in livestock

Reference	BBS/E/D/20231759
Principal Investigator / Supervisor	Professor David Gally
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	1,889,138
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

Although genome sequences for livestock and poultry have recently become available, gene annotation, particularly with respect to immune-related genes, is partial at best. We aim to enhance the current base by undertaking a systems based analysis to identify, annotate and determine the function of key molecules, specifically major sets of pattern recognition receptors (PRR) and the defense pathways they regulate. The research will utilise data from wide-scale transcriptomic studies on early host-pathogen interactions between innate immune cells and economically important bacterial pathogens that breach or manipulate the innate defenses of the host. The functional relevance of PRR to vaccine design will be further explored through molecular studies of their interactions with ligands and modifiers. The outputs will focus on the most important genes and pathways and should translate into interventions, including vaccines and immuno-modulators, that are effective in the appropriate species.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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