Award details

Transcriptomes, networks and systems

Reference	BBS/E/D/20211552
Principal Investigator / Supervisor	Professor John Woolliams
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	1,687,447
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

This project will develop comprehensive gene expression atlases for livestock species. Transcriptome analysis has become routine through the development of microarray technologies, and has been applied to all major livestock species, in part through developments at Roslin/ARK-Genomics. Transcriptome analysis provides a means to: associate genes with normal and disease processes; infer gene function of minimally annotated genes; define cell type origins of primary and cultured cells; identify cell- and pathway- specific signatures from normal and diseased tissues; associate long non-coding RNAs and microRNAs with pathways and function. However, current farm animal transcriptome datasets represent a small fraction of the potential complexity arising from the multi-dimensionality defined by species, tissue/cell, state, and time. We are developing methods in computational biology and the emerging discipline of systems biology, to allow for the comprehensive mapping of cellular and molecular networks and pathways. We will focus on two areas that are central to the Institute: the immune response to pathogen challenge and the role of mesenchymal cells in production traits. This project will contribute directly to other strategic programmes in identifying the transcription networks and expression atlases appropriate to their research.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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