Award details

Tissue and organ development in the intact animal - Agriculture, Animal Welfare, Developmental Biology, Diet and Health , Genetically Modified Organisms

Reference	BBS/E/D/05251443
Principal Investigator / Supervisor	Professor Christopher Whitelaw
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	2,319,295
Status	Completed
Type	Institute Project
Start date	01/08/2008
End date	31/03/2012
Duration	44 months

Abstract

We aim investigate whole animal biology through mechanistic studies. Using the skills and capabilities at The Roslin Institute we are ideally placed to study cellular differentiation at the tissue level in vivo – across a range of species including rodent, poultry, livestock and companion animals. Furthermore, we aim to identify general mechanisms that function across a range of species thus exploiting comparative biology to identify over-arching principles and rate-limiting processes. We aim to compared and contrast cellular differentiation in the foetus or embryo with that in the adult animal and will exploit natural and engineered mutants to achieve these goals. The objectives of the theme are: To define endocrine regulation of ovarian follicular recruitment. To define role of macrophages in embryonic development. To identify centrosome/cilia signalling functions during vertebrate development. To expand application of transgenic technologies in the study of development. To characterise regulation of bone mineralization, growth and differentiation. To assess how early life experiences affect fundamental patterns of organ development and function in the foetus and neonate.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Animal Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search