Award details

The biochemical and molecular basis of resistance to xenobiotics

Reference	BBS/E/C/00084342
Principal Investigator / Supervisor	Dr Stephen Moss
Co-Investigators / Co-Supervisors
Institution	Rothamsted Research
Department	Rothamsted Research Department
Funding type	Research
Value (£)	39,663
Status	Completed
Type	Institute Project
Start date	01/04/2000
End date	31/03/2003
Duration	36 months

Abstract

Key Objective: To identify the molecular and biochemical basis of evolved resistance to herbicides. Background: Many parallels exist between resistance to xenobiotics in plants and animals, including the identification of multi-drug resistance proteins (MRPs) in both systems. Increasingly, cases of resistance to herbicides are being reported world- wide, although only a limited amount is know about the evolved biochemical and molecular basis of resistance. This project aims to employ biochemical and molecular biology techniques to identify the mechanisms responsible for resistance to herbicides at the whole plant level. Approach: On-going work in our laboratory has identified populations of weeds with unique resistance mechanisms, as well as mechanisms of resistance which have been previously reported. Investigations so far have detected novel resistance mechanisms such as a decreased activity of esterase, and biochemical studies completed in our laboratory have also identified populations with a target site alteration which confers resistance. Molecular studies of these populations have begun to identify the ACCase point mutation responsible for this resistance mechanism. The comparison of ACCase sequences between resistant populations will lead to identification of the mutations conferring the different resistance patterns, as yet unreported in arable weeds such as black-grass.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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