Award details

Statistical genomics

Reference	BBS/E/C/00005107
Principal Investigator / Supervisor	Professor Christopher Rawlings
Co-Investigators / Co-Supervisors	Professor Walter Gilks
Institution	Rothamsted Research
Department	Rothamsted Research Department
Funding type	Research
Value (£)	321,447
Status	Completed
Type	Institute Project
Start date	01/04/2010
End date	31/03/2012
Duration	24 months

Abstract

The focus of this project is to develop new state-of-the-art statistical methodology for application in areas of genomics which focus on biomolecular sequence and/or structure and which are of relevance to agriculture. The new wave of high-throughput genomic and proteomic technologies present great and unprecedented opportunities for biological and agricultural science, but simultaneously present great challenges in how to manage, interpret and exploit the concomitant information deluge. Rothamsted Research was the birthplace of mathematical statistics in the early part of the twentieth century, pioneered by the celebrated scientist and statistician R.A.Fisher. Since its inception, the purpose of mathematical statistics has been to distil meaning from experimental and observational data, to reveal underlying statistical and scientific truth. New biotechnology generates new forms of biological data, in hitherto unimaginable quantities. Moreover, such data are often collected to answer new kinds of biological question. To reliably extract information from these new types of data to address these new kinds of question, new statistical methods for experimental design, data analysis and inference are required. Currently, the Statistical Genomics Group is involved in projects on soil metagenomics, crop genetic map integration, crop chromatin structure and fungal genome architecture. Each of these projects involves DNA sequence in some way, in each case the aim of the analysis being to reveal underlying structure of some sort. In each case, we are developing statistical methodology to address the intricate nature of the data and of the questions being asked of them.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Crop Science, Plant Science, Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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