Award details

Lipid transport and metabolism

Reference	BBS/E/C/00004948
Principal Investigator / Supervisor	Professor Frederica Theodoulou
Co-Investigators / Co-Supervisors
Institution	Rothamsted Research
Department	Rothamsted Research Department
Funding type	Research
Value (£)	393,778
Status	Completed
Type	Institute Project
Start date	01/04/2008
End date	31/03/2012
Duration	48 months

Abstract

Acyl-CoA metabolism is central to the partitioning of lipids between different cellular pools and underpins not only our understanding of lipid signalling and metabolism but also the ability to engineer production of high value fatty acids in plants. Although the reversible activation of fatty acids by conversion to CoA esters is now known to be catalysed by a large family of acyl activating enzymes, the relationship between this process and compartmentation of different substrates is poorly defined in plants. Similarly, although the transport of lipids and lipid metabolites such as CoA esters plays key roles in metabolism, signalling and development, the molecular details of these processes remain to be established. This project aims to identify and characterise transporters involved in the movement of fatty acids, acyl CoAs and related molecules across membranes and to elucidate their cellular and physiological roles. A specific goal is to understand how substrates, co-substrates and cofactors of beta-oxidation are imported into peroxisomes and how peroxisomal metabolism is co-ordinated with other cellular compartments. The extent to which non-native lipids are metabolised by beta-oxidation will also be addressed. Longer term aims include the development of methods to assay lipid/metabolite transport, the identification of novel transporters and their roles in lipid compartmentation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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