Award details

Exploiting eIF4E-based and associated broad-spectrum recessive resistance to potyviruses in dicots and monocots

Reference	BBS/E/C/00004841
Principal Investigator / Supervisor	Professor Kim Hammond-Kosack
Co-Investigators / Co-Supervisors	Dr Konstantin Kanyuka
Institution	Rothamsted Research
Department	Rothamsted Research Department
Funding type	Research
Value (£)	107,249
Status	Completed
Type	Institute Project
Start date	02/04/2007
End date	01/04/2010
Duration	36 months

Abstract

The main aim of the proposed project is to exploit sources of recessive eIF4E-based resistance to potyviruses in dicots and monocots including related broad-spectrum resistance. This project is part of the BBSRC 'Innovation in crop science - exploitation of genetics for sustainability' initiative. The following specific objectives will be pursued: Objective 1. Studying the natural allelic variation in eIF4Ee controlling recessive resistance to potyviruses in Brassica rapa and barley and a possible role for eIF(iso)4E in B. rapa . Objective 2. Identifying and characterising novel chemically induced eIF4E and eIF(iso)4E alleles in barley through a TILLING approach. Objective 3. Identifying the gene which in combination with eIF4E provides broad-spectrum resistance to TuMV in the diploid brassica species B. rapa. Objective 4. Producing broadly applicable, transferable molecular markers for superior eIF4E alleles in brassicas and barley and for the additional gene which is involved in broad-spectrum resistance to TuMV in brassicas. Objective 5. Molecular modelling simulation: Homology modelling the 3D protein structure of novel eIF4E variants to predict superior resistance alleles for deployment in breeding and analysis of the interaction between eIF4E and the VPg of bymoviruses and TuMV. The deliverables from the project will be plant lines possessing genes providing new resistances to important viruses, along with allele-specific markers for the genes.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	Crop Science, Microbiology, Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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