Award details

Trehalose signalling: understanding and exploiting an emerging small molecule carbohydrate paradigm

Reference	BBS/E/C/00004766
Principal Investigator / Supervisor	Dr Matthew Paul
Co-Investigators / Co-Supervisors
Institution	Rothamsted Research
Department	Rothamsted Research Department
Funding type	Research
Value (£)	87,013
Status	Completed
Type	Institute Project
Start date	06/02/2006
End date	27/08/2011
Duration	67 months

Abstract

Sucrose and trehalose are the most widespread non-reducing disaccharides in nature. Until recently, with very few exceptions, the division of sucrose and trehalose between the kingdoms was thought to be clear cut. However, the trehalose pathway and trehalose 6-phosphate (T6P), in particular, have now been shown to play an indispensible signalling role in plants. The proposal will determine the signalling partners of T6P and closely related non-reducing disaccharides to enable chemical intervention of physiological function in Arabidopsis through: 1) Synthesis of non-reducing glycan libraries based on the trehalose and sucrose cores 2) Synthesis of small molecule glycan arrays 3) Protein and nucleic acid isolation and screening including construction of Arabidopsis transgenics for T6P target partners4) Construction of in planta active non-reducing mimetics and probes.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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