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Developmental genomics and epigenetics in brassica

Reference	BBS/E/C/00004719
Principal Investigator / Supervisor	Professor Graham King
Co-Investigators / Co-Supervisors
Institution	Rothamsted Research
Department	Rothamsted Research Department
Funding type	Research
Value (£)	837,770
Status	Completed
Type	Institute Project
Start date	01/04/2005
End date	31/03/2008
Duration	36 months

Abstract

The project aims to establish relationships between genome organisation, chromatin structure and crop plant development in Arabidopsis and Oilseed Rape. Specifically, to understand how the interaction between transcriptional regulation and local chromatin organisation affects co-ordination of cellular fate during early embryogenesis, enabling identification of genetic, epigenetic and environmental constraints modulating differentiation. Objectives: 1. Determine changes in global and local changes in chromatin by comparing methylation status, dinucleosome positioning and linker-length variation for specific cis-regulatory regions. 2. Determine sequence-determined preferences for dinucleosome formation in response to changes in cellular status in Arabidopsis. 3. Carry out comparative studies of nucleosome positioning in Arabidopsis and Brassica genomes. 4. Develop models that account for changes in global and local DNA methylation patterns during defined stages of development. 5. Contribute to the Multinational Brassica Genome Project through involvement in integration of genetic, trait, physical and sequence maps.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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