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Hormonal control of subcellular Ca(2+) signalling in ventricular myocytes and Purkinje cells or the rat heart

Reference	BBS/E/B/54971515
Principal Investigator / Supervisor	Dr Martin Bootman
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	4,164
Status	Completed
Type	Institute Project
Start date	01/10/2000
End date	30/09/2003
Duration	36 months

Abstract

Under normal physiological conditions the contraction of each cardiac muscle cells is under the control of the electrical excitation wave sweeping across the entire heart. During the signal transduction process, referred to as excitation-contraction (EC) coupling, the electrical information, the action potential, is translated into a transient increase in the intracellular Ca2+ concentration which evokes the mechanical activity of each individual cardiac myocyte. Sudden cardiac events are one of the major causes for death in the western world. Here, we attempt to understand how various hormones mediate sudden cardiac death and to identify novel drug targets to suppress their action.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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