Award details

Neurotransmitter receptors: molecular pharmacology, novel ligands

Reference	BBS/E/B/51916626
Principal Investigator / Supervisor	Professor David Sattelle
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	5,670
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/1999
Duration	30 months

Abstract

This research aims to enhance our understanding of ionotropic receptors. Objectives include research on dyes appropriate as reporters of target site responses, development and characterisation of novel primary cultures and cell lines together with electrophysiological studies of such cells. Identification and evaluation of novel receptors will be pursued using appropriate technologies. Multidisciplinarity: The project combines receptor molecular cloning, radioligand binding, transient and stable expression and advanced electrophysiology (voltage-clamp, patch-clamp) in the study of neurotransmitter receptor function and pharmacology. The likely benefits of this research are an increased understanding of the function and pharmacology of wild type and mutant ionotropic receptors of Drosophila melanogaster and other insects. Exploitability: The identification and characterisation of known and novel potential molecular targets for insect control agents is of interest to the Agrochemical Industry. This work is sponsored by DuPont. Exploration of optical methods for reporting receptor function may offer new approaches to high-throughput screening. The project is relevant to H&LS and ANRE Foresight and the specific priorities of Drug Creation and Delivery (also AS Biomolecular Design) (as it identifies known and potential targets for bioactive chemicals, notably insecticides); Integrative Biology (as it underpins new developments in molecular genetics, cell biology and physiology); and Diagnostic Applications of Molecular Biology as novel cell lines developed will be used in conjunction with novel optical probes to assay for target site activity of new compounds). Also relevant to AF Animal Health.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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