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The role of NMDA-receptor and intracellular calcium signalling genes in mouse olfactory learning

Reference	BBS/E/B/47976461
Principal Investigator / Supervisor	Professor Keith Kendrick
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	115,869
Status	Completed
Type	Institute Project
Start date	01/06/2000
End date	31/05/2003
Duration	36 months

Abstract

This project aims to investigate the precise role of a specific signalling pathway in the brain (NMDA receptor/calcium)which is of key importance to learning and memory function. In particular it will take advantage of existing strains of transgenic mice with targeted deletion, or over-expression of genes, involved in this signalling pathway. Novel and rapid behavioural tests involving olfactory memory paradigms will be used to identify whether the animals have impaired, or improved, ability to form and retain memories. Neurophysiological and neuroanatomical approaches will then be used to identify what precise changes have occurred in neural and neurochemical transmission and expression of genes and proteins in brain regions involved in olfactory memory formation. The main aims of these studies are to provide a better understanding of how this signalling pathway is used to form and retain memories. They are ultimately designed to help identify new potential therapeutic targets for alleviation of cognitive dysfunction in humans resulting from ageing, neuropathological diseases such as Alzheimer¿s, or developmental or psychiatric disorders

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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