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Transgenic mice as models of Alzheimers disease; focus on calcium binding proteins as targets
Reference
BBS/E/B/47966718
Principal Investigator / Supervisor
Dr Piers Emson
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
28,408
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/1999
Duration
30 months
Abstract
The entry of Ca2+ underlies the majority of neuronal signalling events in the CNS. Disturbance in calcium homeostasis leads to neuronal degeneration. In this project transgenic mice deficient in a major calcium binding protein calbindin D28K will be examined as models of human neurological disease. Mice will be examined for learning and memory deficits and increasing pathology with age. The research is relevant to Foresight priorities in Integrative Biology, Neuroscience and Ageing and investigates one of the major economically important diseases affecting the elderly in the EC. The mice may be of considerable economic importance if established as neurological disease models. The project benefits from our established collaboration with pharmaceutical companies.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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