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Assessments of altered cholinergic, monoaminergic & aminoacid transmitter release as a function of ageing & in Alzhimers transgenic mouse models

Reference	BBS/E/B/47001167
Principal Investigator / Supervisor	Professor Keith Kendrick
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	660,406
Status	Completed
Type	Institute Project
Start date	01/09/1999
End date	30/08/2004
Duration	60 months

Abstract

In vivo neurochemical sampling methods will be used to assess changes in basal and evoked-release of hippocampal, frontal cortex and striatal transmitters as a function of normal ageing in rats and mice and in transgenic mouse lines that express various aspects of brain pathology and cognitive dysfunction associated with Alzheimer¿s disease. Therapeutic actions of novel anti-cholinesterase inhibitors or drugs affecting other transmitter systems affected will be assessed both in terms of in vivo neurochemical changes and altered cognitive functioning. Overall therefore this project aims to identify genes and transmitters specifically involved in cognitive decline during ageing or neuropathology and is therefore directly relevant to Foresight H&LS priorities in molecular and cellular Neurobiology, cognitive sciences and ageing. The project involves extensive national and international, academic and industrial collaborations which will all aid discovery of novel drugs for treatment of Alzheimer¿s disease.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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