Award details

Interactions between T cells and epithelial cells

Reference	BBS/E/B/36001140
Principal Investigator / Supervisor	Dr Peter Kilshaw
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	118,868
Status	Completed
Type	Institute Project
Start date	01/04/1998
End date	31/03/2000
Duration	24 months

Abstract

The aim is to understand the role of T cells in the immunological defence of mucosal surfaces, particularly with regard to the functional interactions that occur between T cells, epithelial cells and dendritic cells in mucosal epithelia. The objectives are(i) to investigate the molecular pathways that are available for adhesion, signalling and co- stimulation between lymphocytes and epithelial cells and (ii) to manipulate genetically the cytokine environment of the mucosal immune system by targeted gene expression. The work involves a multidisciplinary approach, integrating molecular biology with the study of immunity at a clinical/whole animal level(H&LS Foresight, Integrative biology). The project is directly relevant to the H&LS Foresight priorities on Manipulating the Immune System(control of tolerance in chronic inflammation and vaccination) and Drug creation and delivery. The project has a direct bearing on the control of chronic inflammatory processes at mucosal surfaces. The potential benefits will be new therapies for inflammatory bowel disease, novel strategies for immunisation at mucosal surfaces and new research tools (e.g. a mucosal lymphocyte- specific gene promoter).The potential benefits will be new therapies for inflammatory bowel disease, novel strategies for immunisation at mucosal surfaces and new research tools (e.g. a mucosal lymphocyte- specific gene promoter. To facilitate the research and ensure close interaction with the clinical situation and possibilities for exploitation we collaborate with clinical researchers and immunologists at St Bartholomews Hospital, London and the Universities of Utah, Stanford and Hamburg and benefit from specific collaborations on related projects in the laboratory (e.g. 36001040) with two UK pharmaceutical companies.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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