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Genes of the major histocompatibility complex in laboratory rats
Reference
BBS/E/B/32001174
Principal Investigator / Supervisor
Dr Geoff Butcher
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
492,969
Status
Completed
Type
Institute Project
Start date
30/09/2000
End date
31/08/2003
Duration
35 months
Abstract
In all vertebrate species so far studied an extensive cluster of genes involved in the immune response has been identified. This has been named 'Major Histocompatibility Complex' (MHC) on account of the leading role that it also plays in provoking the rejection of grafts transplanted between members of the same species. Some of these MHC genes encode cell-surface proteins called MHC class I and II molecules which can bind peptides and 'present' them to T lymphocytes, thereby provoking immune responses, or which regulate the activity of Natural Killer lymphocytes. Other MHC genes participate in the generation of peptides for presentation or in other aspects of immunity. The project aims to accumulate detailed knowledge of the MHC in the laboratory rat, which is a major species for enquiring into the basis of immunological disease in mammals.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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