Award details

Identification and functional analysis of imprinted genes

Reference	BBS/E/B/21976602
Principal Investigator / Supervisor	Dr Gavin Kelsey
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	18,234
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	30/09/2000
Duration	42 months

Abstract

We inherit a set of genes from our mother and from our father. For most genes, both copies are equally active irrespective of their parentage. A few genes defy this expectation: only one copy of an theirimprintedthat gene is normally expressed. Consequently, developmental processes in which imprinted genes function are especially susceptible to the effect of mutation. For example, problems in imprinting give rise to disturbances in fetal growth which, in addition to immediate clinical implications, may predispose to diseases in later life, such as hypertension and diabetes. It is not known how many of our genes are controlled by imprinting. We are using a molecular landmark to identify all the imprinted genes present in mammals. This work will create important diagnostic markers for growth and other disorders in which imprinting is suspected to be a factor, and pave the way for new therapeutic strategies with which to treat them.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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