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Functional analysis of imprinted genes involved in placental development

Reference	BBS/E/B/21976466
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	43,916
Status	Completed
Type	Institute Project
Start date	01/05/2000
End date	01/05/2003
Duration	36 months

Abstract

This project aims to investigate development and function of the placenta. The placenta connects the baby to the mother during pregnancy and provides all of its nutritional and oxygen requirements. There are a number of genes known to be important in development whereby only one copy (either motherthats or fatherthats) is active. This is known as parental gene imprinting and it is very important that the correct pattern of each parentthats genes is expressed. Abnormal expression during development can lead to disease, including cancers. This study will establish how the imprinted genes ensure correct placental development in mice and will also assess how defects in development due to abnormal gene expression can affect placental function. The work will provide basic information on the development of a very important organ, the placenta, will establish the function of some of the imprinted genes and will provide much needed information on the relationship between the structural components of the placenta and its efficiency at transferring nutrients to the embryo.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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