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Gene targeting at imprinted loci: investigating neural and behavioural phenotypes

Reference	BBS/E/B/21001169
Principal Investigator / Supervisor	Dr Gavin Kelsey
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	389,313
Status	Completed
Type	Institute Project
Start date	01/04/2000
End date	31/03/2003
Duration	36 months

Abstract

We inherit a set of genes from our mother and from our father. For most genes, both copies are equally active irrespective of their parentage. A few genes defy this expectation: only one copy of an imprinted gene is normally expressed. Consequently, developmental processes in which imprinted genes function are especially susceptible to the effect of mutation. Imprinting is particularly important in aspects of growth control of the fetus and neurological effects in infants. We have identified new imprinted genes by screening the mammalian genome. In order to understand fully the function of these genes, we need to remove them selectively from specific cells in which they are expressed. We shall do this by deleting the gene from these cells by gene targeting. We are particularly interested in achieving this for imprinted genes active in neuroendocrine cells which control the production of many of the hormones of our bodies.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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