BBSRC Portfolio Analyser
Award details
Vertebrate Polycomb and Trithorax gene function
Reference
BBS/E/B/21001162
Principal Investigator / Supervisor
Dr Stephen Gaunt
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
302,449
Status
Completed
Type
Institute Project
Start date
01/04/2000
End date
31/03/2004
Duration
48 months
Abstract
The developmental fate of embryonic cells becomes permanently fixed by binding of Polycomb and Trithorax group proteins to their DNA. This maintains certain genes in an active state, and others in an inactive state. Polycomb and Trithorax group proteins therefore provide a cellular memory mechanism that is stably inherited from one cell generation to the next. Loss of this may be important in cancer, especially certain types of leukaemias. We wish to test the role of the vertebrate M33 and Mll genes upon memory of Hox expression profiles and developmental fate in embryonic tissues.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search