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The establishment of Hox gene expression patterns in vertebrate embryos
Reference
BBS/E/B/21001161
Principal Investigator / Supervisor
Dr Stephen Gaunt
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
302,449
Status
Completed
Type
Institute Project
Start date
01/04/2000
End date
31/03/2004
Duration
48 months
Abstract
The body plan of a developing mouse, human or chick embryo is specified by the 39 Hox genes. These are differentially expressed along the embryo in a series of partially overlapping domains. A central question in developmental biology is that of how these domains are established. We have shown that they develop by spreading from the posterior end, with anterior genes spreading forward ahead of more posterior genes. We have published models of how a gradient of morphogen along the early embryo could account for these developing patterns. Various lines of circumstantial evidence suggest that this morphogen could be the combined effects of the three so-called caudal proteins. In future work, we shall test the roles of caudal, Hox and related genes in the establishment of Hox expression patterns.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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