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A transgenic approach to investigate the regulation of skeletal muscle differentiation
Reference
BBS/E/B/21001131
Principal Investigator / Supervisor
Dr Jennifer Pell
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
738,305
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
30/09/2000
Duration
42 months
Abstract
During development, many cells undergo a period of proliferation before evolving into the differentiated cells which form parts of specialised tissues. The mechanisms and timing of these events are important as differentiated cells usually do not proliferate and therefore leave a fixed population size. Myogenesis, the process by which proliferating myoblasts permanently exit from the cell cycle and form differentiated myotubules, is an excellent paradigm for such development. Indeed, it has been shown that growth rate in animals can be related to primary myotube number. The aim of this project is to investigate the factors and pathways that control the process of myogenesis. The initial aim is to determine the role of key growth factors and their binding proteins.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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