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Novel immune GTPases regulating lymphocyte apoptosis/survival

Reference	BBS/E/B/000H0116
Principal Investigator / Supervisor	Dr Geoff Butcher
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	22,710
Status	Completed
Type	Institute Project
Start date	01/10/2010
End date	30/09/2013
Duration	36 months

Abstract

Mature T and B lymphocytes are the essential mediators of specific immunity and immunological memory in vertebrates. Characteristic features of these cells are their long life (months to years) and their relative quiescence, which is maintained unless and until they encounter a ‘cognate’ substance (an antigen) that can activate them to respond and to initiate a protective immune response. The maintenance of the long lifespan and quiescence of lymphocytes is now recognised to require the active engagement of several signalling pathways. It is also appreciated that a healthy and diverse lymphocyte repertoire can contribute significantly to healthy ageing. Our work is focussed on one family of proteins, the GIMAP GTPases, some of which are required for lymphocyte survival. By using unbiased approaches to identifying proteins which interact with members of the GIMAP family we aim to understand more about the mechanisms underlying lymphocyte survival in general and to uncover new ways whereby lymphocytes may be manipulated to enhance or to suppress immune responsiveness, where desirable.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Immunology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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