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Developmental dynamics of the epigenome

Reference	BBS/E/B/000C0403
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors	Dr Myriam Hemberger, Dr Gavin Kelsey, Prof. Llewelyn Roderick, Dr Peter Rugg-Gunn
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	3,137,621
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

This Theme examines in detail the mechanisms and genome-wide dynamics of reprogramming and programming events in GCs and early embryos, in tissues during ageing as well as the biology involved. It builds directly upon the resource established in Theme 1, and adds value to it. It also involves analysis of additional epigenomes, e.g. in conditional knockouts or transgenics of epigeetic modifiers. The objectives are to determine the mechanistic basis of: (1) epigenetic reprogramming in PGCs, (2) programng in later stage GCs, (3) reprogramming in early embryos (4), programming during early lineage commitment to ICM, TE, and PE, and derived stem cells (5), imprinting and transgenerational inheritance (6,) Influence of ageing upon the epigenome of the non-replicating genome of cardiac myocytes and effects thereof upon cardiac adaptation.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Ageing, Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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