Award details

Signalling to the developing epigenome

Reference	BBS/E/B/000C0402
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors	Dr Myriam Hemberger, Dr Gavin Kelsey, Prof. Llewelyn Roderick, Dr Peter Rugg-Gunn
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	1,621,517
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

Key signalling events are important in making developmental decisions (eg lineage commitment, gastrulation) and we focus on understanding the connections between signalling systems and the epigenome. Furthermore, it is possible that environmental and nutritional states signal, potentially through the same cascades, to the epigenome, thus resulting in durable and potentially heritable ch anges much later in life and across generations. We are addressing the following objectives: (1) FGF4 and MAPK/ERK signalling in cell fate switch between ES and TS cells and induced changes to the epigenome, (2) the role played by FGF signalling and Pc silencing in gastrulation, (3) the effects of diet on the epigenomes of metabolic control centres in the brain, and (4) signalling pathways in mediating environmental regulation of the epigenome in controlling cardiomyocyte hypertrophy

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Neuroscience and Behaviour, Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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