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Non-coding RNAs and transcription as epigenetic regulators
Reference
BBS/E/B/000C0401
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Dr Jonathan Houseley
,
Dr Gavin Kelsey
,
Prof. Llewelyn Roderick
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
301,115
Status
Completed
Type
Institute Project
Start date
01/04/2012
End date
31/03/2017
Duration
59 months
Abstract
Transcription and ncRNAs are major modifiers of the epigenetic state, but the mechanisms by which they act are still poorly understood. In this Theme, we investigate the role of ncRNAs, initially using a yeast model system, (1) in genome stability, (2) their influence on meiotic recombination, (3) the role of antisense ncRNAs in chromatin structure modulation, and in mice (4) how transcription promotes DNA methylation at imprinted loci.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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