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Systematic characterisation of epigenomes and transcriptomes during early mouse development

Reference	BBS/E/B/000C0400
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors	Dr Myriam Hemberger, Dr Jonathan Houseley, Dr Gavin Kelsey, Prof. Llewelyn Roderick, Dr Peter Rugg-Gunn
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	2,324,784
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

Work in this Theme provides an unprecedented opportunity for this grouping of PIs and for the national and international scientific community to establish reference epigenomes for the key stages of epigenetic reprogramming and programming in germ cells, preimplantation embryos, and lineage commitment in early postimplantation embryos. This resource together with the development of an integrated epigenomics database will underpin the biological exploration of epigenetic reprogramming mechanisms, the unravelling of signalling principles that pattern the epigenome during development and ageing, and the understanding of how non-coding RNAs regulate the epigenome. This resource will become available to the national and international community through established high quality links (eg EU Network of Excellence, IHEC) and will be of great value not only for the epigenetics community, but also for developmental biologists, geneticists, reproductive and evolutionary biologists, stem cell researchers, and those working on the biology of ageing

Summary

unavailable

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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